Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MC4R | P32245 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10848812 | 0.90 | PDE4B (0.55) | MAPTSMN1; SMN2GAATP53PAX8 | |
| SCHEMBL10738294 | 0.84 | MAPT (0.43) | MAPTSMN1; SMN2GAATP53PAX8 | |
| SCHEMBL10742091 | 0.80 | MEN1 (0.43) | MAPTSMN1; SMN2GAATP53NPSR1 | |
| SCHEMBL23494012 | 0.80 | MAPT (0.70) | MAPTSMN1; SMN2GAATP53PAX8 | |
| SCHEMBL31307884 | 0.80 | MAPT (0.70) | MAPTSMN1; SMN2GAATP53PAX8 | |
| SCHEMBL10566652 | 0.77 | PDE4B (0.54) | MAPTSMN1; SMN2GAATP53NPSR1 | |
| SCHEMBL10509852 | 0.76 | MEN1 (0.44) | MAPTSMN1; SMN2GAATP53NPSR1 | |
| SCHEMBL10846042 | 0.76 | PDE4B (0.51) | MAPTSMN1; SMN2GAATP53NPSR1 | |
| SCHEMBL5332891 | 0.75 | PAX8 (0.83) | MAPTSMN1; SMN2GAATP53PAX8 | |
| SCHEMBL8326169 | 0.75 | DYRK1A (0.54) | MAPTSMN1; SMN2GAATP53PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | claimed |
| US-4621089-A | Pyrazolopyridine derivatives and their use in treating inflammation and allergic conditions | BEECHAM GROUP P.L.C. (GB) | 1986-11-04 | — | — | US | disclosed |
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | disclosed |