Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10567101 | 0.84 | HPGD (0.37) | HPGD | |
| SCHEMBL10563794 | 0.83 | HCAR3 (0.41) | ALDH1A1MAPK1KDM4ERAB9AHSD17B10 | |
| SCHEMBL10566652 | 0.83 | PDE4B (0.54) | MEN1KMT2APKMALDH1A1PDE4B | |
| SCHEMBL10567519 | 0.82 | JAK3 (0.38) | MAPTGAA | |
| SCHEMBL10846042 | 0.82 | PDE4B (0.51) | MEN1KMT2APKMALDH1A1PDE4B | |
| SCHEMBL10848812 | 0.77 | PDE4B (0.55) | MEN1KMT2APKMALDH1A1PDE4B | |
| SCHEMBL10848760 | 0.76 | MAPT (0.50) | MEN1KMT2AALDH1A1PDE4BMAPK1 | |
| SCHEMBL10564142 | 0.76 | KMT2A (0.43) | MEN1KMT2APKMALDH1A1MAPK1 | |
| SCHEMBL10565260 | 0.75 | KMT2A (0.51) | MEN1KMT2APKMALDH1A1PDE4B | |
| SCHEMBL10853045 | 0.74 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0152910-B1 | PYRAZOLOPYRIDINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1989-07-12 | — | — | EP | disclosed |
| US-4837238-A | Pharmacologically useful pyrazolopyridines | BEECHAM GROUP P.L.C. (GB) | 1989-06-06 | — | — | US | disclosed |
| US-4670432-A | Pyrazolopyridine derivatives useful in treating inflammation and allergic conditions | BEECHAM GROUP P.L.C. (GB) | 1987-06-02 | — | — | US | disclosed |
| US-4621089-A | Pyrazolopyridine derivatives and their use in treating inflammation and allergic conditions | BEECHAM GROUP P.L.C. (GB) | 1986-11-04 | — | — | US | disclosed |
| EP-0193329-A2 | Pyrazolopyridines, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1986-09-03 | — | — | EP | disclosed |
| EP-0154220-A2 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | disclosed |
| EP-0152910-A2 | pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1985-08-28 | — | — | EP | disclosed |