Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10848812 | 0.85 | PDE4B (0.55) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL10848760 | 0.84 | MAPT (0.50) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL10742091 | 0.81 | MEN1 (0.43) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL10566652 | 0.75 | PDE4B (0.54) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL10846042 | 0.74 | PDE4B (0.51) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL10509852 | 0.74 | MEN1 (0.44) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL10565260 | 0.72 | KMT2A (0.51) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL10848778 | 0.70 | MAPT (0.63) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL10738745 | 0.68 | TGFBR1 (0.49) | AURKA | |
| SCHEMBL11244977 | 0.66 | ALDH1A1 (0.78) | MAPTTP53SMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0207593-A1 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1987-01-07 | — | — | EP | claimed |
| US-4716160-A | Certain 7-amino-pyrazolo[4,3-b]pyridines useful in treating inflammatory and allergic disorders | BEECHAM GROUP P.L.C. (GB) | 1987-12-29 | — | — | US | disclosed |
| EP-0207593-A1 | Pyrazolopyridine derivatives | BEECHAM GROUP PLC (GB) | 1987-01-07 | — | — | EP | disclosed |