Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.50 |
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SORD | Q00796 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10847822 | 0.86 | RAB9A (0.39) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL10850376 | 0.72 | ALDH1A1 (0.44) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL8526236 | 0.70 | RAB9A (0.73) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL3550190 | 0.70 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL10849969 | 0.70 | ALDH1A1 (0.44) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL1713549 | 0.69 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL11783793 | 0.69 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL7217567 | 0.69 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL21047628 | 0.69 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL11377536 | 0.69 | HRH3 (0.47) | RAB9ANPC1SMN1; SMN2CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4622401-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0070376-A1 | Heterocyclic substituted-amino-pyrazolines | AMERICAN CYANAMID COMPANY (US) | 1983-01-26 | — | — | EP | disclosed |
| US-4268436-A | OXIDATIVE DIAZOTIZATION WITH NITROSYLSULFURIC ACID, ALKALINE METAL NITRITES, OR ALKYL NITRITES | AZIENDE COLORI NAZIONALI AFFINI ACNA S.P.A. (IT) | 1981-05-19 | — | — | US | disclosed |