Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CASR | P41180 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10853398 | 0.83 | CASR (0.48) | MEN1KMT2AHTTSMN1; SMN2CASR | |
| SCHEMBL10851543 | 0.79 | BCHE (0.44) | MEN1KMT2AHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL9768795 | 0.77 | HTR7 (0.35) | MEN1KMT2ACYP3A4LMNACHRM2 | |
| SCHEMBL10849315 | 0.77 | MEN1 (0.42) | MEN1KMT2AHTTSMN1; SMN2CASR | |
| SCHEMBL16263333 | 0.74 | PKM (0.35) | MEN1KMT2A | |
| SCHEMBL10855574 | 0.74 | HTT (0.43) | MEN1KMT2AHTTSMN1; SMN2CASR | |
| SCHEMBL10854824 | 0.74 | ESR1 (0.36) | MEN1KMT2ACHRM2CHRM1SLC6A4 | |
| SCHEMBL10849661 | 0.70 | GAA (0.47) | CYP3A4CHRM2CHRM1CYP2D6CYP2C19 | |
| SCHEMBL295321 | 0.69 | PKM (0.38) | KMT2AHTTSMN1; SMN2LMNA | |
| SCHEMBL9768971 | 0.69 | PKM (0.38) | KMT2AHTTSMN1; SMN2LMNAADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4563458-A | CIRCULATORY SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-01-07 | — | — | US | disclosed |
| EP-0114374-A1 | Substituted 4-aminomethylene chromans or chromenes, process for their preparation and their use in medicines | BAYER AG (DE) | 1984-08-01 | — | — | EP | disclosed |