Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 10/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9295115 | 0.90 | ADORA2B (0.64) | ADORA2BLMNASMN1; SMN2POLBMAPT | |
| SCHEMBL10063431 | 0.88 | LMNA (0.80) | ADORA2BLMNASMN1; SMN2POLBMAPT | |
| SCHEMBL10967466 | 0.86 | ADORA2B (0.69) | ADORA2BLMNASMN1; SMN2POLBMAPT | |
| SCHEMBL18399526 | 0.83 | ADORA2B (0.68) | ADORA2BLMNASMN1; SMN2POLBMAPT | |
| SCHEMBL16120984 | 0.82 | ADORA2B (0.81) | ADORA2BLMNASMN1; SMN2POLBMAPT | |
| SCHEMBL11539363 | 0.82 | ADORA2B (0.67) | ADORA2BLMNASMN1; SMN2POLBMAPT | |
| SCHEMBL9293623 | 0.81 | ADORA2B (0.63) | ADORA2BLMNASMN1; SMN2POLBMAPT | |
| SCHEMBL9294398 | 0.81 | ADORA2B (0.63) | ADORA2BLMNASMN1; SMN2POLBMAPT | |
| SCHEMBL10858566 | 0.81 | LMNA (0.73) | ADORA2BLMNASMN1; SMN2POLBMAPT | |
| SCHEMBL8443037 | 0.81 | ADORA2B (0.77) | ADORA2BLMNASMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4576947-A | HYDROXYALKYLXANTHINES, INCREASING CEREBRAL BLOOD FLOW, BRONCHODILATORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-03-18 | — | — | US | disclosed |
| US-4515795-A | INSUFFICIENCY OF CEREBRAL BLOOD FLOW | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-05-07 | — | — | US | disclosed |