Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CDC25B | P30305 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MDM4 | O15151 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28888587 | 0.97 | MAPT (0.36) | MAPTHDAC8 | |
| SCHEMBL3076493 | 0.77 | MAPT (0.35) | MAPTHDAC8 | |
| SCHEMBL19696748 | 0.69 | CYP3A4 (0.52) | MAPTHDAC8 | |
| SCHEMBL80679 | 0.69 | CYP3A4 (0.52) | MAPTHDAC8 | |
| SCHEMBL16582039 | 0.67 | MAPT (0.45) | MAPTHDAC8MEN1CDC25BKMT2A | |
| SCHEMBL29365040 | 0.67 | — | — | |
| SCHEMBL63240 | 0.67 | — | — | |
| SCHEMBL28897771 | 0.67 | MGLL (0.33) | MEN1KMT2A | |
| SCHEMBL15477575 | 0.67 | CYP3A4 (0.47) | MAPTMEN1KMT2A | |
| SCHEMBL1227488 | 0.67 | ALDH1A1 (0.47) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120208291-A1 | METHODS AND COMPOSITIONS FOR MEASURING HIGH AFFINITY INTERACTIONS WITH KINETIC IMAGING OF SINGLE MOLECULE INTERACTION (KISMI) | UNIVERISTY OF UTAH RESEARCH FOUNDATION (US) | 2012-08-16 | — | — | US | disclosed |
| EP-2424971-A1 | METHODS AND COMPOSITIONS FOR MEASURING HIGH AFFINITY INTERACTIONS WITH KINETIC IMAGING OF SINGLE MOLECULE INTERACTION (KISMI) | University of Utah Research Foundation (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010127247-A1 | METHODS AND COMPOSITIONS FOR MEASURING HIGH AFFINITY INTERACTIONS WITH KINETIC IMAGING OF SINGLE MOLECULE INTERACTION (KISMI) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208291-A1 | METHODS AND COMPOSITIONS FOR MEASURING HIGH AFFINITY INTERACTIONS WITH KINETIC IMAGING OF SINGLE MOLECULE INTERACTION (KISMI) | MPI, MKI67, GDI2 | MAPT 1921/4885HDAC8 4026/4885MEN1 1680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.