Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10857092 | 0.85 | PTGES (0.40) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL10855623 | 0.85 | RECQL (0.41) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL10857588 | 0.85 | SYK (0.43) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL10857088 | 0.82 | RECQL (0.40) | ALDH1A1GAAHPGDMKNK1MKNK2 | |
| SCHEMBL10857210 | 0.81 | CA1 (0.37) | ALDH1A1SIRT3GAAHPGDCYP1A2 | |
| SCHEMBL10854337 | 0.81 | RECQL (0.39) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL10852319 | 0.81 | RECQL (0.39) | ALDH1A1F7F3SARM1SIRT2 | |
| SCHEMBL11238745 | 0.81 | LMNA (0.38) | ALDH1A1SIRT2L3MBTL1LMNA | |
| SCHEMBL10856096 | 0.80 | HDAC3 (0.44) | ALDH1A1HPGDRECQLNPC1RAB9A | |
| SCHEMBL10860776 | 0.79 | MAPT (0.44) | ALDH1A1GAAL3MBTL1THRBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4565826-A | HYPOTENSIVE, CARDIONASCULAR, ANTIULCER, ANTISECRETORY, GASTROINTESTINAL DISORDERS | WILLIAM H. RORER, INC. (US) | 1986-01-21 | — | — | US | disclosed |
| US-4436911-A | HYPOTENSIVE, ANTISPASMODIC, ANTIULCER, ANTIPARASITIC | WILLIAM H. RORER, INC. (US) | 1984-03-13 | — | — | US | disclosed |