Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 1/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 10/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20828256 | 0.78 | TYMP (0.65) | TYMPNR3C1NR3C2SMN1; SMN2KDM4E | |
| SCHEMBL29974905 | 0.75 | TYMP (0.49) | TYMPNR3C1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4667572 | 0.75 | TYMP (0.65) | TYMPNR3C1NR3C2SMN1; SMN2KDM4E | |
| SCHEMBL2672214 | 0.75 | TYMP (1.00) | TYMPNR3C1NR3C2KDM4EALDH1A1 | |
| SCHEMBL5197218 | 0.72 | TYMP (0.57) | TYMPNR3C1NR3C2SMN1; SMN2KDM4E | |
| SCHEMBL10853896 | 0.71 | TYMP (0.56) | TYMPSMN1; SMN2KDM4EALDH1A1HTT | |
| SCHEMBL10857015 | 0.71 | LMNA (0.70) | SMN1; SMN2ALDH1A1TSHRHTTLMNA | |
| Diphenylmethane SCHEMBL10711103 | 0.70 | CALM1 (0.63) | TYMPNR3C1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9353995 | 0.70 | TYMP (0.54) | TYMPNR3C1NR3C2SMN1; SMN2KDM4E | |
| SCHEMBL6300080 | 0.69 | DHFR (0.48) | TYMPNR3C1KDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4600720-A | HISTAMINE H2-ANTOAGONISTS, ANTISECRETORY; THIAZOLINE, QUINAZOLINE, QUINOLINE, PYRIMIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1986-07-15 | — | — | US | disclosed |
| US-4578459-A | HISTAMINE H2-ANTAGONISTS | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-03-25 | — | — | US | disclosed |
| US-4537779-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-08-27 | — | — | US | disclosed |
| US-4470985-A | HISTAMINE H-2 ANTAGONISTS | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-09-11 | — | — | US | disclosed |
| US-4467087-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-08-21 | — | — | US | disclosed |
| US-4399142-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-08-16 | — | — | US | disclosed |
| US-4374251-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-02-15 | — | — | US | disclosed |
| US-4341787-A | ANTIHISTAMINES; ANTISECRETORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1982-07-27 | — | — | US | disclosed |
| US-4282221-A | Pharmacologically active compounds to inhibit H-2 histamine receptors | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-08-04 | — | — | US | disclosed |
| US-4260744-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-04-07 | — | — | US | disclosed |
| US-4181730-A | ANTISECRETORY AGENTS, IMIDAZOLYALKYLIMIDAZOLINONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-01-01 | — | — | US | disclosed |
| US-4153793-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-08 | — | — | US | disclosed |
| US-4104381-A | HISTAMINE INHIBITORS, ((IMIDAZOLYLALKYL)AMINO)THIADIAZINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-01 | — | — | US | disclosed |