Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 6/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL10346445 | 0.82 | CA5A (0.33) | CA5ACA5BMAPT | |
| SCHEMBL23515650 | 0.79 | MAPT (0.34) | MAPTGSRCA2 | |
| SCHEMBL196429 | 0.78 | — | — | |
| SCHEMBL209944 | 0.78 | — | — | |
| SCHEMBL23284422 | 0.78 | — | — | |
| SCHEMBL29016131 | 0.78 | THRB (0.41) | — | |
| Nitric Acid SCHEMBL10598415 | 0.76 | CA5A (0.42) | CA5ACA5BMAPTGSR | |
| Hydrochloric Acid SCHEMBL28195227 | 0.75 | — | — | |
| Isosorbide SCHEMBL217707 | 0.74 | THRB (0.65) | CA5ACA5BMAPTGSRCA2 | |
| Isosorbide SCHEMBL5699287 | 0.74 | THRB (0.65) | CA5ACA5BMAPTGSRCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0195462-A2 | Diesel fuel composition | ETHYL CORPORATION (US) | 1986-09-24 | — | — | EP | claimed |
| EP-0101093-A2 | Diesel fuel composition | ETHYL CORPORATION (US) | 1984-02-22 | — | — | EP | claimed |
| US-4405335-A | TETRAHYDROFURANDION DINITRATE ANTIKNOCK FUEL ADDITIVE | ETHYL CORPORATION (US) | 1983-09-20 | — | — | US | claimed |
| EP-0195462-A2 | Diesel fuel composition | ETHYL CORPORATION (US) | 1986-09-24 | — | — | EP | disclosed |
| US-4536190-A | MIXTURE OF NITRIC ACID ESTERS OF BI(OR TRI-)=CYCLIC ALCOHOLS AND ORGANIC NITRATES | ETHYL CORPORATION (US) | 1985-08-20 | — | — | US | disclosed |
| US-4473378-A | BLEND OF ALKYL NITRATE AND CETANE IMPROVER | ETHYL CORPORATION (US) | 1984-09-25 | — | — | US | disclosed |
| EP-0101093-A2 | Diesel fuel composition | ETHYL CORPORATION (US) | 1984-02-22 | — | — | EP | disclosed |
| US-4405335-A | TETRAHYDROFURANDION DINITRATE ANTIKNOCK FUEL ADDITIVE | ETHYL CORPORATION (US) | 1983-09-20 | — | — | US | disclosed |