Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isosorbide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isosorbide SCHEMBL3388024 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL2129898 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL4353400 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL5699287 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL5170125 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL27944142 | 0.90 | THRB (0.65) | THRBLMNAMAPTALDH1A1GSR | |
| Isosorbide SCHEMBL8414428 | 0.84 | THRB (0.56) | THRBLMNAMAPTALDH1A1GSR | |
| Isosorbide Mononitrate SCHEMBL919022 | 0.83 | MAPT (0.93) | THRBLMNAMAPTALDH1A1GSR | |
| Isosorbide SCHEMBL24465084 | 0.81 | THRB (1.00) | THRBLMNAMAPTBCHE | |
| Isosorbide SCHEMBL6298736 | 0.81 | THRB (1.00) | THRBLMNAMAPTBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1657 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117924280-B | Substituted thienyl-5-fluoro-1H-pyrazolopyridine compound and application thereof | 中国人民解放军军事科学院军事医学研究院 | 2024-07-12 | — | — | CN | claimed |
| CN-118173886-A | Sodium ion battery electrolyte and sodium ion battery | 中国科学院大连化学物理研究所 | 2024-06-11 | — | — | CN | claimed |
| CN-117924280-A | Substituted thienyl-5-fluoro-1H-pyrazolopyridine compound and application thereof | 中国人民解放军军事科学院军事医学研究院 | 2024-04-26 | — | — | CN | claimed |
| CN-117790893-A | Electrolyte and lithium battery containing same | 蜂巢能源科技股份有限公司 | 2024-03-29 | — | — | CN | claimed |
| CN-117650279-A | Nonaqueous electrolyte and lithium metal battery | 蜂巢能源科技股份有限公司 | 2024-03-05 | — | — | CN | claimed |
| CN-117414439-A | Medicine composite material and preparation method and application thereof | 中国科学院理化技术研究所 | 2024-01-19 | — | — | CN | claimed |
| CN-117179146-A | Methane inhibitor and application thereof in feed preparation | 河南农业大学 | 2023-12-08 | — | — | CN | claimed |
| CN-117164657-A | Prodrugs of directed lymphatics | 莫纳什大学 | 2023-12-05 | — | — | CN | claimed |
| CN-117088931-A | Prodrugs of directed lymphatics | 莫纳什大学 | 2023-11-21 | — | — | CN | claimed |
| CN-116979040-A | Silicon-based material with improved performance by adopting small molecular electrolyte and button cell | 河南工程学院 | 2023-10-31 | — | — | CN | claimed |
| EP-0766579-A1 | PULSATILE DELIVERY SYSTEMS OF BIOLOGICALLY ACTIVE AGENTS USING ELECTRO VOLTAGE PULSING FOR CONTROLLING MEMBRANE PERMEABILITY | CYGNUS, INC. (US) | 1997-04-09 | — | — | EP | claimed |
| EP-0475536-B1 | Spherical granules having core and their production | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-04-02 | — | — | EP | claimed |
| US-5516531-A | CORES SPRAY COATED WITH POWDERS OF DRUGS AND HYDROXYPROPYL CELLULOSE FOR CENTRAL NERVOUS SYSTEMS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-05-14 | — | — | US | claimed |
| WO-1996000111-A1 | PULSATILE DELIVERY SYSTEMS OF BIOLOGICALLY ACTIVE AGENTS USING ELECTRO VOLTAGE PULSING FOR CONTROLLING MEMBRANE PERMEABILITY | CYGNUS, INC. (US) | 1996-01-04 | — | — | WO | claimed |
| EP-0656881-A1 | ESTER AND COMBINATIONS OF AN ORGANIC NITRATE AND A SALICYLATE | CAL INTERNATIONAL LIMITED (IE) | 1995-06-14 | — | — | EP | claimed |
| WO-1994003421-A2 | ESTERS AND COMBINATIONS OF AN ORGANIC NITRATE AND A SALICYLATE | CAL INTERNATIONAL LIMITED (IE) | 1994-02-17 | — | — | WO | claimed |
| US-5120546-A | TRANSDERMAL SYSTEM | PHARMACIA AB (SE) | 1992-06-09 | — | — | US | claimed |
| EP-0475536-A1 | Spherical granules having core and their production | Takeda Chemical Industries, Ltd. (JP) | 1992-03-18 | — | — | EP | claimed |
| US-4976965-A | CARDIOVASCULAR DISORDERS | KALI-CHEMIE PHARMA GMBH (DE) | 1990-12-11 | — | — | US | claimed |
| EP-0277741-A1 | Spherical granules having core and their production | Takeda Chemical Industries, Ltd. (JP) | 1988-08-10 | — | — | EP | claimed |