Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isosorbide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isosorbide SCHEMBL3388024 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL217707 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL2129898 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL4353400 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL5170125 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL27944142 | 0.90 | THRB (0.65) | THRBLMNAMAPTALDH1A1GSR | |
| Isosorbide SCHEMBL8414428 | 0.84 | THRB (0.56) | THRBLMNAMAPTALDH1A1GSR | |
| Isosorbide Mononitrate SCHEMBL919022 | 0.83 | MAPT (0.93) | THRBLMNAMAPTALDH1A1GSR | |
| Isosorbide SCHEMBL24465084 | 0.81 | THRB (1.00) | THRBLMNAMAPTBCHE | |
| Isosorbide SCHEMBL6298736 | 0.81 | THRB (1.00) | THRBLMNAMAPTBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682097-A2 | NON-TABLETTED, CHEWABLE, INDIVIDUALLY DOSED ADMINISTRATION FORMS | Almirall Prodesfarma, S.A. (ES) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005048974-A2 | NON-TABLETTED, CHEWABLE, INDIVIDUALLY DOSED ADMINISTRATION FORMS | ALMIRALL PRODESFARMA, S.A. (ES) | 2005-06-02 | — | — | WO | disclosed |