Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10872357 | 0.90 | KMT2A (0.40) | KMT2AMEN1KDM4EGAAMAPK1 | |
| SCHEMBL3731770 | 0.88 | MAPT (0.43) | KMT2AMEN1GAAMAPTPDE3A | |
| SCHEMBL10372875 | 0.87 | GPR88 (0.39) | KMT2AMEN1MAPTPDE3ASLC22A6 | |
| SCHEMBL10547877 | 0.83 | KMT2A (0.40) | KMT2AMEN1KDM4EGAAMAPK1 | |
| SCHEMBL10770220 | 0.83 | MAPT (0.36) | KDM4EGAAMAPK1MAPTPDE3A | |
| SCHEMBL11423312 | 0.80 | MAPT (0.39) | KMT2AMEN1GAAMAPTPDE3A | |
| SCHEMBL10530994 | 0.78 | PDE3A (0.38) | KMT2AMEN1KDM4EGAAMAPK1 | |
| SCHEMBL11404409 | 0.78 | TDP1 (0.41) | KMT2AMEN1KDM4EGAAMAPK1 | |
| SCHEMBL9327248 | 0.78 | MAPT (0.46) | KMT2AMEN1GAAMAPTPDE3A | |
| SCHEMBL9567734 | 0.78 | MAPT (0.46) | KMT2AMEN1GAAMAPTPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0191989-A1 | Antibiotic isoxazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1986-08-27 | — | — | EP | disclosed |