Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10874855 | 0.90 | ALDH1A1 (0.42) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL10875612 | 0.88 | TOP2A (0.43) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL10875671 | 0.86 | TOP2A (0.54) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL6217926 | 0.86 | TOP2A (0.45) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL10874969 | 0.86 | ALDH1A1 (0.52) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL10927140 | 0.85 | TOP2A (0.45) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL10648280 | 0.84 | LMNA (0.44) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL9635148 | 0.83 | ALDH1A1 (0.41) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL10648861 | 0.83 | ALDH1A1 (0.41) | TOP2ATOP2BALDH1A1POLBOPRM1 | |
| SCHEMBL10509964 | 0.83 | TOP2A (0.44) | TOP2ATOP2BALDH1A1POLBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0203488-A2 | 7-Azolyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinoline carboxylic acids and 1,8-naphthyridine carboxylic acids, process for their preparation and bactericidal agents containing them | BAYER AG (DE) | 1986-12-03 | — | — | EP | disclosed |