Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891904 | 0.73 | SLC6A3 (0.44) | PARP3SLC6A3SLC6A2CHRNB2CHRNA4 | |
| SCHEMBL612073 | 0.72 | PDE4A (0.41) | CYP3A4ADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL2792608 | 0.71 | MAOB (0.48) | PARP3SLC6A3CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL2790840 | 0.68 | SLC6A3 (0.41) | PARP3SLC6A3MTNR1ASIGMAR1 | |
| SCHEMBL10725693 | 0.68 | MTNR1A (0.42) | PARP3SLC6A3MTNR1AMEN1CYP3A4 | |
| SCHEMBL10720882 | 0.68 | MTNR1A (0.42) | PARP3SLC6A3MTNR1AMEN1CYP3A4 | |
| SCHEMBL10721311 | 0.68 | MTNR1A (0.42) | PARP3SLC6A3MTNR1AMEN1CYP3A4 | |
| SCHEMBL3150368 | 0.67 | MAPK1 (0.56) | MTNR1AMEN1KMT2AMAPK1 | |
| SCHEMBL3159001 | 0.67 | MAPK1 (0.56) | MTNR1AMEN1KMT2AMAPK1 | |
| SCHEMBL531338 | 0.67 | MAPK1 (0.56) | MTNR1AMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0201085-A2 | 6-Phenyl-1,2,3,4,4a,5,6,10b-octahydrobenz(h) isoquinolines | PENNWALT CORPORATION (US) | 1986-11-12 | — | — | EP | disclosed |