Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | TOP2A | P11388 | 8/20 | 0.53 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.53 |
| ▸ | DHFR | P00374 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5142702 | 0.88 | DPP4 (0.58) | DPP4CHRM2DRD1TOP2ATOP2B | |
| SCHEMBL9437304 | 0.88 | TOP2A (0.58) | DPP4CHRM2DRD1TOP2ATOP2B | |
| SCHEMBL500472 | 0.85 | DPP4 (0.57) | DPP4CHRM2DRD1TOP2ATOP2B | |
| SCHEMBL10330767 | 0.85 | TOP2A (0.59) | DPP4CHRM2DRD1TOP2ATOP2B | |
| SCHEMBL10876616 | 0.85 | DPP4 (0.56) | DPP4CHRM2DRD1TOP2ATOP2B | |
| SCHEMBL10876239 | 0.85 | DPP4 (0.45) | DPP4CHRM2DRD1TOP2ATOP2B | |
| SCHEMBL17537044 | 0.83 | DPP4 (0.56) | DPP4CHRM2DRD1TOP2ATOP2B | |
| SCHEMBL14143514 | 0.82 | DPP4 (0.54) | DPP4CHRM2DRD1TOP2ATOP2B | |
| SCHEMBL14472239 | 0.82 | DPP4 (0.56) | DPP4CHRM2DRD1TOP2ATOP2B | |
| SCHEMBL10413901 | 0.82 | DPP4 (0.55) | DPP4CHRM2DRD1TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0203488-A2 | 7-Azolyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinoline carboxylic acids and 1,8-naphthyridine carboxylic acids, process for their preparation and bactericidal agents containing them | BAYER AG (DE) | 1986-12-03 | — | — | EP | disclosed |