Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.56 |
| ▸ | TOP2A | P11388 | 8/20 | 0.53 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16213450 | 0.86 | DPP4 (0.52) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL10330767 | 0.85 | TOP2A (0.59) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL5142702 | 0.84 | DPP4 (0.58) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL9437304 | 0.84 | TOP2A (0.58) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL10876232 | 0.82 | DPP4 (0.59) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL500472 | 0.82 | DPP4 (0.57) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL12665410 | 0.82 | LMNA (0.43) | DPP4TOP2ATOP2BKDM4EALDH1A1 | |
| SCHEMBL14143514 | 0.82 | DPP4 (0.54) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL13014061 | 0.82 | DPP4 (0.54) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL9669861 | 0.81 | DPP4 (0.68) | DPP4TOP2ATOP2BCHRM2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250413-B2 | C-25 carbamate rifamycin derivatives with activity against drug-resistant microbes | CUMBRE PHARMACEUTICALS INC. (US) | 2007-07-31 | — | — | US | disclosed |