Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 8/20 | 0.59 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.59 |
| ▸ | DPP4 | P27487 | 6/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9437304 | 0.88 | TOP2A (0.58) | TOP2ATOP2BDPP4CHRM2DRD1 | |
| SCHEMBL5142702 | 0.88 | DPP4 (0.58) | TOP2ATOP2BDPP4CHRM2DRD1 | |
| SCHEMBL4747719 | 0.86 | TOP2A (0.47) | TOP2ATOP2BDPP4CHRM2DRD1 | |
| SCHEMBL500472 | 0.85 | DPP4 (0.57) | TOP2ATOP2BDPP4CHRM2DRD1 | |
| SCHEMBL10876232 | 0.85 | DPP4 (0.59) | TOP2ATOP2BDPP4CHRM2DRD1 | |
| SCHEMBL14472239 | 0.85 | DPP4 (0.56) | TOP2ATOP2BDPP4CHRM2DRD1 | |
| SCHEMBL13014061 | 0.85 | DPP4 (0.54) | TOP2ATOP2BDPP4CHRM2DRD1 | |
| SCHEMBL14143514 | 0.85 | DPP4 (0.54) | TOP2ATOP2BDPP4CHRM2DRD1 | |
| SCHEMBL17537044 | 0.83 | DPP4 (0.56) | TOP2ATOP2BDPP4CHRM2DRD1 | |
| SCHEMBL10876616 | 0.82 | DPP4 (0.56) | TOP2ATOP2BDPP4CHRM2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861401-B1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2015-11-18 | — | — | EP | disclosed |
| US-8222407-B2 | Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-07-17 | — | — | US | disclosed |
| US-8222407-B2 | Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-07-17 | — | — | US | disclosed |
| US-20100197909-A1 | MUTILIN DERIVATIVE HAVING HETEROCYCLIC AROMATIC RING CARBOXYLIC ACID STRUCTURE IN SUBTITUENT AT 14-POSITION | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
| US-20100197909-A1 | MUTILIN DERIVATIVE HAVING HETEROCYCLIC AROMATIC RING CARBOXYLIC ACID STRUCTURE IN SUBTITUENT AT 14-POSITION | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
| US-7732612-B2 | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-06-08 | — | — | US | disclosed |
| US-7687629-B2 | Process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate | LG LIFE SCIENCES LTD. (KR) | 2010-03-30 | — | — | US | disclosed |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
| US-20070282107-A1 | New process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate | LG LIFE SCIENCES LTD. | 2007-12-06 | — | — | US | disclosed |
| US-7271272-B2 | Process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate | LG LIFE SCIENCES LTD. (KR) | 2007-09-18 | — | — | US | disclosed |
| US-7232907-B2 | Process for production of naphthyridine-3-carboxylic acid derivatives | LG LIFE SCIENCES LIMITED (KR) | 2007-06-19 | — | — | US | disclosed |
| US-7199242-B2 | Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof | LG LIFE SCIENCES LIMITED (KR) | 2007-04-03 | — | — | US | disclosed |
| US-7179805-B2 | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282107-A1 | New process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate | MLN, AAAS, ACMSD | TOP2A 69/4885TOP2B 46/4885DPP4 104/4885 |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | NQO2, QRFPR, NQO1 | TOP2A 389/4885TOP2B 359/4885DPP4 1254/4885 |
| US-20100197909-A1 | MUTILIN DERIVATIVE HAVING HETEROCYCLIC AROMATIC RING CARBOXYLIC ACID STRUCTURE IN SUBTITUENT AT 14-POSITION | PELP1, MLN, SND1 | TOP2A 3897/4885TOP2B 4117/4885DPP4 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.