Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.58 |
| ▸ | TOP2A | P11388 | 7/20 | 0.55 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9437304 | 0.90 | TOP2A (0.58) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL500472 | 0.88 | DPP4 (0.57) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL10876232 | 0.88 | DPP4 (0.59) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL10330767 | 0.88 | TOP2A (0.59) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL9279260 | 0.88 | DPP4 (0.55) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL17537044 | 0.85 | DPP4 (0.56) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL10413901 | 0.84 | DPP4 (0.55) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL14472239 | 0.84 | DPP4 (0.56) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL13014061 | 0.84 | DPP4 (0.54) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL14143514 | 0.84 | DPP4 (0.54) | DPP4TOP2ATOP2BCHRM2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4663457-A | BACTERICIDES | WARNER-LAMBERT COMPANY (US) | 1987-05-05 | — | — | US | claimed |
| US-7304050-B2 | Antibacterial agents | PFIZER INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7098219-B2 | Quinolone derivatives | WOCKHART LIMITED (IN) | 2006-08-29 | — | — | US | disclosed |
| EP-1670793-A1 | ANTIBACTERIAL AGENTS | Warner-Lambert Company LLC (US) | 2006-06-21 | — | — | EP | disclosed |
| US-7012144-B2 | Quinolone carboxylic acid derivatives | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2006-03-14 | — | — | US | disclosed |
| US-20050070523-A1 | Antibacterial agents | HAGEN SUSAN (US) | 2005-03-31 | — | — | US | disclosed |
| WO-2005026161-A1 | ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-24 | — | — | WO | disclosed |
| US-20030130302-A1 | Quinolone carboxylic acid derivatives | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2003-07-10 | — | — | US | disclosed |
| US-20020177559-A1 | Quinolone derivatives | WOCKHARDT LIMITED | 2002-11-28 | — | — | US | disclosed |
| US-5631266-A | BACTERICIDES EFFECTIVE AGAINST STAPHYLOCOCCUS | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1997-05-20 | — | — | US | disclosed |
| US-5498615-A | BROAD SPECTRUM ANTIBACTERIALS | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1996-03-12 | — | — | US | disclosed |
| WO-1994025464-A1 | NOVEL QUINOLONE CARBOXYLIC ACID DERIVATIVES AND PROCESS FOR PREPARING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1994-11-10 | — | — | WO | disclosed |
| EP-0622367-A1 | Novel quinolone carboxylic acid derivatives and process for preparing the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1994-11-02 | — | — | EP | disclosed |
| EP-0153828-B1 | 1-CYCLOPROPYL-1, 4-DIHYDRO-6-FLUORO-4-OXO-1, 8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS; THEIR DERIVATIVES AND A PROCESS FOR PREPARING THE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1990-12-27 | — | — | EP | disclosed |
| US-4663457-A | BACTERICIDES | WARNER-LAMBERT COMPANY (US) | 1987-05-05 | — | — | US | disclosed |
| EP-0153828-A2 | 1-cyclopropyl-1, 4-dihydro-6-fluoro-4-oxo-1, 8-naphthyridine-3-carboxylic acids; their derivatives and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-09-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070523-A1 | Antibacterial agents | MRPL21, ABCB11, NQO1 | DPP4 1617/4885TOP2A 28/4885TOP2B 54/4885 |
| US-20030130302-A1 | Quinolone carboxylic acid derivatives | CYCS, CBR3, HCCS | DPP4 1704/4885TOP2A 257/4885TOP2B 328/4885 |
| US-20020177559-A1 | Quinolone derivatives | ABCB11, ABCB1, ABCG2 | DPP4 819/4885TOP2A 293/4885TOP2B 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.