Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of 2-Piperazin-1-Yl-Pyrimidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL10880395 | 1.00 | KDM4E (0.68) | KDM4EALDH1A1CYP3A4HSD17B10TSHR | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL10876592 | 0.85 | KDM4E (0.70) | KDM4EALDH1A1CYP3A4HSD17B10TSHR | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL28926339 | 0.84 | KDM4E (0.75) | KDM4EALDH1A1CYP3A4HSD17B10TSHR | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL893739 | 0.84 | ALDH1A1 (0.95) | KDM4EALDH1A1CYP3A4HSD17B10TSHR | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL169214 | 0.84 | ALDH1A1 (0.95) | KDM4EALDH1A1CYP3A4HSD17B10TSHR | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL26600776 | 0.82 | KDM4E (0.66) | KDM4EALDH1A1CYP3A4HSD17B10TSHR | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL101561 | 0.82 | ALDH1A1 (1.00) | KDM4EALDH1A1CYP3A4HSD17B10TSHR | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL5375472 | 0.82 | ALDH1A1 (0.91) | KDM4EALDH1A1CYP3A4HSD17B10TSHR | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL924147 | 0.82 | ALDH1A1 (1.00) | KDM4EALDH1A1CYP3A4HSD17B10TSHR | |
| 2-Piperazin-1-Yl-Pyrimidine SCHEMBL27920766 | 0.82 | ALDH1A1 (0.91) | KDM4EALDH1A1CYP3A4HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109340-B1 | ACID SALTS OF 2-PIPERAZINOPYRIMIDINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1986-04-16 | — | — | EP | claimed |