Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL11090823 | 0.99 | ALDH1A1 (0.34) | ALDH1A1MEN1KMT2AATMGAA | |
| SCHEMBL9492368 | 0.94 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AATMGAA | |
| SCHEMBL9492364 | 0.94 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AATMGAA | |
| Phosphoric Acid SCHEMBL11096435 | 0.94 | MEN1 (0.32) | ALDH1A1MEN1KMT2A | |
| Phosphoric Acid SCHEMBL11089876 | 0.85 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AATMGAA | |
| SCHEMBL10878445 | 0.83 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AATMGAA | |
| SCHEMBL10878440 | 0.83 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AATMGAA | |
| SCHEMBL9494852 | 0.81 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AATMGAA | |
| SCHEMBL9494847 | 0.81 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AATMGAA | |
| SCHEMBL9491360 | 0.81 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2AATMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0085275-B1 | SUBSTITUTED THIAZOLIDINYLIC ESTERS OF MINERAL ACIDS | CIBA-GEIGY AG (CH) | 1986-02-19 | — | — | EP | claimed |
| US-4489069-A | ANTITUMOR | CIBA-GEIGY AG (CH) | 1984-12-18 | — | — | US | claimed |
| US-4582841-A | ANTITUMOR AND -CARCINOGENIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1986-04-15 | — | — | US | disclosed |
| US-4489069-A | ANTITUMOR | CIBA-GEIGY AG (CH) | 1984-12-18 | — | — | US | disclosed |