Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.41 |
| ▸ | RXRB | P28702 | 5/20 | 0.41 |
| ▸ | RXRG | P48443 | 5/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10880896 | 1.00 | RXRA (0.41) | RXRARXRBRXRGSMPD1HDAC1 | |
| SCHEMBL10948152 | 0.87 | RXRB (0.40) | RXRARXRBRXRGALDH1A1KDM4E | |
| SCHEMBL10948147 | 0.87 | RXRB (0.40) | RXRARXRBRXRGALDH1A1KDM4E | |
| SCHEMBL10880158 | 0.85 | MRGPRX4 (0.53) | RXRARXRBRXRGMAPTALDH1A1 | |
| SCHEMBL10881123 | 0.84 | ALDH1A1 (0.42) | RXRARXRBRXRGSMPD1HDAC1 | |
| SCHEMBL11721107 | 0.81 | NPC1 (0.39) | RXRARXRBRXRGSMPD1HDAC1 | |
| SCHEMBL11721103 | 0.81 | NPC1 (0.39) | RXRARXRBRXRGSMPD1HDAC1 | |
| SCHEMBL10881120 | 0.81 | MAPT (0.42) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11720977 | 0.79 | RXRA (0.51) | RXRARXRBRXRGMAPTALDH1A1 | |
| SCHEMBL11720690 | 0.79 | RAB9A (0.47) | RXRARXRBRXRGMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109815-B1 | IMPROVEMENTS IN AND RELATING TO SUBSTITUTED TETRAHYDRONA PHTHALENES | ELI LILLY AND COMPANY (US) | 1986-05-28 | — | — | EP | disclosed |
| US-4500545-A | HYPOTENSIVE, ANTISECRETORY AGENTS, AND DOPAMINE ANTAGONIST | ELI LILLY AND COMPANY (US) | 1985-02-19 | — | — | US | disclosed |
| EP-0109815-A1 | Improvements in and relating to substituted tetrahydrona phthalenes | ELI LILLY AND COMPANY (US) | 1984-05-30 | — | — | EP | disclosed |
| US-4448990-A | Hydroxyaminotetralincarboxamides | ELI LILLY AND COMPANY (US) | 1984-05-15 | — | — | US | disclosed |