SCHEMBL10881024

SCHEMBL10881024

Nc1c(O)ccc(S(=O)(=O)O)c1N

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AURKA O14965 1/20 0.46
AURKB Q96GD4 1/20 0.46
ALDH1A1 P00352 4/20 0.45
HSD17B10 Q99714 3/20 0.45
NQO1 P15559 1/20 0.42
COMT P21964 1/20 0.42
LDHA P00338 1/20 0.41
TTR P02766 1/20 0.39
NT5E P21589 3/20 0.39
TSHR P16473 1/20 0.38
LMNA P02545 3/20 0.38
HPGD P15428 1/20 0.38
HIF1A Q16665 1/20 0.38
MAPT P10636 2/20 0.38
GAA P10253 1/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38
TDP1 Q9NUW8 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27881048 0.88 TTR (0.46) AURKAAURKBALDH1A1HSD17B10NQO1
SCHEMBL3936702 0.84 NQO1 (0.45) AURKAAURKBALDH1A1HSD17B10NQO1
Hydrochloric Acid SCHEMBL11264863 0.83 NQO1 (0.44) AURKAAURKBALDH1A1HSD17B10NQO1
SCHEMBL8755118 0.83 AURKA (0.43) AURKAAURKBALDH1A1HSD17B10NQO1
SCHEMBL3030721 0.80 AURKA (0.53) AURKAAURKBALDH1A1HSD17B10NQO1
SCHEMBL9680157 0.79 AURKA (0.47) AURKAAURKBALDH1A1HSD17B10NQO1
SCHEMBL30638077 0.78 AURKB (0.60) AURKAAURKBALDH1A1HSD17B10NQO1
SCHEMBL11593636 0.78 AURKB (0.60) AURKAAURKBALDH1A1HSD17B10NQO1
SCHEMBL9338896 0.77 CA2 (0.41) AURKAAURKBALDH1A1HSD17B10COMT
SCHEMBL15309350 0.76 DAPK1 (0.43) AURKAAURKBALDH1A1HSD17B10LDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0093369-B1 REACTIVE DYES BAYER AG (DE) 1986-07-23 EP disclosed
EP-0093369-A2 Reactive dyes BAYER AG (DE) 1983-11-09 EP disclosed