Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | FPR2 | P25090 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10886473 | 0.91 | HDAC8 (0.53) | KMT2AATMFPR2HDAC8F2 | |
| SCHEMBL330061 | 0.91 | CTSL (0.55) | ITGB3ITGA2BALDH1A1CTSLCTSS | |
| SCHEMBL5486969 | 0.91 | CTSL (0.55) | ITGB3ITGA2BALDH1A1CTSLCTSS | |
| SCHEMBL8976911 | 0.91 | CTSL (0.55) | ITGB3ITGA2BALDH1A1CTSLCTSS | |
| SCHEMBL9800635 | 0.89 | KMT2A (0.63) | KMT2AATMFPR2HDAC8ITGB3 | |
| SCHEMBL19065242 | 0.89 | GPR34 (0.58) | HDAC8ITGB3ITGA2BPTPN1GPR34 | |
| SCHEMBL19065177 | 0.89 | MME (0.56) | ITGB3ITGA2BCTSLCTSSCTSK | |
| SCHEMBL13588070 | 0.89 | MME (0.56) | ITGB3ITGA2BCTSLCTSSCTSK | |
| SCHEMBL16485550 | 0.88 | CTSL (0.53) | ITGB3ITGA2BALDH1A1CTSLCTSS | |
| SCHEMBL7044299 | 0.88 | ATM (0.67) | KMT2AATMFPR2HDAC8ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2484688-A1 | PEPTIDE EPOXYKETONES FOR PROTEASOME INHIBITION | Onyx Therapeutics, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| EP-0071926-B1 | NEW RIBOFURANURONIC ACID DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-08 | — | — | EP | disclosed |
| US-4479942-A | Tetrahydrofurnancarboxylic acid derivatives, processes for preparation thereof and pharmaceutical compositions thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-10-30 | — | — | US | disclosed |