Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10881527 | 0.83 | HRH2 (0.43) | KMT2AL3MBTL1ADRA2CHRH2HRH1 | |
| SCHEMBL10883693 | 0.79 | KMT2A (0.39) | KMT2AADRA2CHRH2HRH1HRH4 | |
| SCHEMBL10883114 | 0.74 | MAP3K8 (0.43) | KMT2AL3MBTL1ADRA2CHRH2HRH1 | |
| SCHEMBL11047774 | 0.73 | HTR3A (0.46) | L3MBTL1HRH2HRH1HRH4HRH3 | |
| SCHEMBL2473376 | 0.73 | BRD4 (0.58) | TP53GAAMAPTMAPK1HSD17B10 | |
| SCHEMBL10883500 | 0.73 | TP53 (0.47) | TP53GAAMAPTMAPK1HSD17B10 | |
| SCHEMBL11047575 | 0.72 | TAAR1 (0.51) | L3MBTL1HRH2HRH1HRH4HRH3 | |
| SCHEMBL10883557 | 0.71 | GAA (0.51) | GAAKMT2AALDH1A1WDR5 | |
| SCHEMBL10884619 | 0.70 | MAPT (0.47) | TP53GAAMAPTMAPK1HSD17B10 | |
| SCHEMBL10741491 | 0.69 | HRH2 (0.55) | L3MBTL1HRH2HRH1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0081324-B1 | SUBSTITUTED PHARMACOLOGICALLY ACITVE IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1986-08-06 | — | — | EP | disclosed |
| US-4517198-A | Diuretic imidazole derivatives | FARMOS GROUP LTD. (FI) | 1985-05-14 | — | — | US | disclosed |
| EP-0081324-A2 | Substituted pharmacologically acitve imidazole derivatives and their preparation and use | Farmos Group Ltd. (FI) | 1983-06-15 | — | — | EP | disclosed |