Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.40 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | CD44 | P16070 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10881527 | 0.84 | HRH2 (0.43) | MAP3K8SMN1; SMN2HRH2HRH1HRH4 | |
| SCHEMBL10883693 | 0.84 | KMT2A (0.39) | MAP3K8SMN1; SMN2HRH2HRH1HRH4 | |
| SCHEMBL10883557 | 0.78 | GAA (0.51) | MAP3K8SMN1; SMN2WDR5KMT2A | |
| SCHEMBL10885778 | 0.74 | TP53 (0.47) | HRH2HRH1HRH4HRH3TDP1 | |
| SCHEMBL10882622 | 0.73 | WDR5 (0.49) | MAP3K8SMN1; SMN2HRH2HRH1HRH4 | |
| SCHEMBL10885165 | 0.69 | FABP4 (0.37) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL10884796 | 0.68 | ADRA2A (0.37) | SMN1; SMN2HRH2SLC47A1KMT2AADRA2A | |
| SCHEMBL11047575 | 0.66 | TAAR1 (0.51) | SMN1; SMN2HRH2HRH1HRH4HRH3 | |
| SCHEMBL19936723 | 0.66 | MAP3K8 (0.45) | MAP3K8SMN1; SMN2HRH2HRH1HRH4 | |
| SCHEMBL5791428 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0081324-B1 | SUBSTITUTED PHARMACOLOGICALLY ACITVE IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1986-08-06 | — | — | EP | disclosed |
| US-4517198-A | Diuretic imidazole derivatives | FARMOS GROUP LTD. (FI) | 1985-05-14 | — | — | US | disclosed |