Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904702 | 0.82 | SMN1; SMN2 (0.40) | PPARATSHRDRD2DRD4DRD3 | |
| SCHEMBL10890581 | 0.81 | CA1 (0.48) | CYP3A4APPNQO1MAPTCA1 | |
| SCHEMBL2149793 | 0.81 | ACHE (0.41) | CYP3A4TSHRNQO1MAPTLMNA | |
| SCHEMBL28412753 | 0.81 | CYP1A2 (0.57) | CYP1A2CYP3A4PPARATSHRPMP22 | |
| SCHEMBL593487 | 0.79 | LMNA (0.47) | CYP1A2CYP3A4PPARAAPPMAOB | |
| SCHEMBL12013094 | 0.79 | LTA4H (0.48) | HTR2ACYP1A2CYP3A4TSHRAPP | |
| SCHEMBL20710750 | 0.79 | APP (0.36) | APPNQO1MAOBMAPTLMNA | |
| Selenium SCHEMBL29756444 | 0.79 | CA1 (0.46) | CYP3A4APPNQO1MAPTCA1 | |
| SCHEMBL16286430 | 0.79 | CYP1A2 (0.42) | CYP1A2TSHRAPPNQO1MAOB | |
| SCHEMBL10887022 | 0.79 | KDM4E (0.42) | HTR2ASLC6A4SLC6A2SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4591583-A | TREATING VIRAL INFECTIONS | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1986-05-27 | — | — | US | disclosed |
| US-4536400-A | VIRICIDES | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1985-08-20 | — | — | US | disclosed |
| US-4386081-A | VIRICIDE | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1983-05-31 | — | — | US | disclosed |
| US-4372894-A | VIRICIDES | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1983-02-08 | — | — | US | disclosed |
| EP-0003007-B1 | ALIPHATIC DERIVATIVES OF PHOSPHONOFORMIC ACID, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR COMBATING VIRUS INFECTIONS | Astra Läkemedel Aktiebolag (SE) | 1982-04-07 | — | — | EP | disclosed |
| EP-0003275-B1 | AROMATIC DERIVATIVES OF PHOSPHONOFORMIC ACID, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE FOR COMBATING VIRUS INFECTIONS | Astra Läkemedel Aktiebolag (SE) | 1981-09-02 | — | — | EP | disclosed |
| EP-0003275-A1 | Aromatic derivatives of phosphonoformic acid, processes for their preparation, pharmaceutical compositions containing them and their use for combating virus infections | Astra Läkemedel Aktiebolag (SE) | 1979-08-08 | — | — | EP | disclosed |
| EP-0003007-A2 | Aliphatic derivatives of phosphonoformic acid, pharmaceutical compositions and methods for combating virus infections | Astra Läkemedel Aktiebolag (SE) | 1979-07-11 | — | — | EP | disclosed |