Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | CTSS | P25774 | 1/20 | 0.55 |
| ▸ | CTSK | P43235 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10895416 | 1.00 | CTSL (0.55) | CTSLCTSSCTSKEPHX2MAPT | |
| SCHEMBL10887845 | 1.00 | CTSL (0.55) | CTSLCTSSCTSKEPHX2MAPT | |
| SCHEMBL10895418 | 1.00 | CTSL (0.55) | CTSLCTSSCTSKEPHX2MAPT | |
| SCHEMBL9443881 | 0.88 | EPHX2 (0.46) | CTSLCTSSCTSKEPHX2MAPT | |
| SCHEMBL8469271 | 0.83 | CA2 (0.43) | CTSLCTSSCTSKEPHX2MAPT | |
| SCHEMBL11203776 | 0.82 | CTSL (0.51) | CTSLCTSSCTSKMAPTMEN1 | |
| SCHEMBL10886904 | 0.81 | CTSL (0.50) | CTSLCTSSCTSKMEN1KMT2A | |
| SCHEMBL10896800 | 0.81 | CTSL (0.50) | CTSLCTSSCTSKMEN1KMT2A | |
| SCHEMBL8991232 | 0.81 | CTSL (0.50) | CTSLCTSSCTSKMEN1KMT2A | |
| SCHEMBL10896823 | 0.81 | CTSL (0.50) | CTSLCTSSCTSKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080942-B1 | NOVEL INTERMEDIATES AND PROCESS FOR PREPARING (S)-3-ACYLAMINO-4-SUBSTITUTED-2-AZETIDINONES | E.R. Squibb & Sons, Inc. (US) | 1986-02-26 | — | — | EP | disclosed |
| US-4421686-A | 4-Norbornyl-sulfonyl azetidinone intermediates and process for preparing (S)-3-acylamino-4-substituted-2-azetidinones | E. R. SQUIBB & SONS, INC. (US) | 1983-12-20 | — | — | US | disclosed |
| EP-0080942-A1 | Novel intermediates and process for preparing (S)-3-acylamino-4-substituted-2-azetidinones | E.R. Squibb & Sons, Inc. (US) | 1983-06-08 | — | — | EP | disclosed |