Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11487482 | 0.88 | KMT2A (0.33) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL11363297 | 0.86 | KMT2A (0.32) | BRD4ALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10542287 | 0.86 | MTNR1A (0.38) | MTNR1AMTNR1BITGB1 | |
| SCHEMBL10884861 | 0.84 | ALDH1A1 (0.35) | BRD4ALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL11538730 | 0.81 | KMT2A (0.34) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL8014019 | 0.80 | KDM4E (0.38) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL8019417 | 0.80 | KDM4E (0.38) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL11542905 | 0.77 | ALDH1A1 (0.32) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL11473393 | 0.77 | KMT2A (0.33) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL9443885 | 0.77 | MEN1 (0.35) | ALDH1A1KMT2AMEN1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080942-B1 | NOVEL INTERMEDIATES AND PROCESS FOR PREPARING (S)-3-ACYLAMINO-4-SUBSTITUTED-2-AZETIDINONES | E.R. Squibb & Sons, Inc. (US) | 1986-02-26 | — | — | EP | disclosed |
| US-4421686-A | 4-Norbornyl-sulfonyl azetidinone intermediates and process for preparing (S)-3-acylamino-4-substituted-2-azetidinones | E. R. SQUIBB & SONS, INC. (US) | 1983-12-20 | — | — | US | disclosed |
| EP-0080942-A1 | Novel intermediates and process for preparing (S)-3-acylamino-4-substituted-2-azetidinones | E.R. Squibb & Sons, Inc. (US) | 1983-06-08 | — | — | EP | disclosed |