Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prochlorperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 9/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 7/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 7/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 7/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 7/20 | 1.00 |
| ▸ | HTR2A | P28223 | 7/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 7/20 | 1.00 |
| ▸ | HRH1 | P35367 | 7/20 | 1.00 |
| ▸ | DRD3 | P35462 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | TP53 | P04637 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | HTR1A | P08908 | 6/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 6/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 6/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 6/20 | 1.00 |
| ▸ | HTR2C | P28335 | 6/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prochlorperazine SCHEMBL29358207 | 1.00 | DRD2 (1.00) | DRD2MAPTMAPK1ADRA2AADRA2C | |
| Prochlorperazine SCHEMBL29369439 | 1.00 | DRD2 (1.00) | DRD2MAPTMAPK1ADRA2AADRA2C | |
| Prochlorperazine SCHEMBL18429 | 1.00 | DRD2 (1.00) | DRD2MAPTMAPK1ADRA2AADRA2C | |
| Prochlorperazine SCHEMBL133595 | 0.99 | DRD2 (0.98) | DRD2MAPTMAPK1ADRA2AADRA2C | |
| Prochlorperazine SCHEMBL2506559 | 0.99 | DRD2 (0.98) | DRD2MAPTMAPK1ADRA2AADRA2C | |
| Prochlorperazine SCHEMBL1041250 | 0.99 | DRD2 (0.98) | DRD2MAPTMAPK1ADRA2AADRA2C | |
| Perphenazine SCHEMBL28086447 | 0.94 | MAPT (0.91) | DRD2MAPTMAPK1ADRA2AADRA2C | |
| Perphenazine SCHEMBL5307579 | 0.94 | MAPT (0.91) | DRD2MAPTMAPK1ADRA2AADRA2C | |
| Prochlorperazine SCHEMBL10891828 | 0.93 | MAPT (0.90) | DRD2MAPTMAPK1ADRA2AADRA2C | |
| SCHEMBL13485632 | 0.93 | MAPT (0.86) | DRD2MAPTMAPK1ADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012163990-A1 | SGLT-2 INHIBITORS FOR TREATING METABOLIC DISORDERS IN PATIENTS TREATED WITH NEUROLEPTIC AGENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-12-06 | — | — | WO | disclosed |