Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11150174 | 0.91 | ALDH1A1 (0.49) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL10899758 | 0.85 | ALDH1A1 (0.43) | ALDH1A1HPGDS1PR2S1PR1S1PR3 | |
| SCHEMBL10924599 | 0.77 | TSHR (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL6055497 | 0.76 | PDE4D (0.48) | ALDH1A1SMN1; SMN2MEN1KMT2AHDAC3 | |
| SCHEMBL24866002 | 0.75 | SMPD1 (0.41) | ALDH1A1HPGDCHUKDAPK3JAK2 | |
| SCHEMBL30867116 | 0.75 | SMPD1 (0.41) | ALDH1A1HPGDCHUKDAPK3JAK2 | |
| SCHEMBL9250450 | 0.74 | SMPD1 (0.43) | ALDH1A1HPGDS1PR3CHUKDAPK3 | |
| SCHEMBL14976645 | 0.74 | ALDH1A1 (0.50) | ALDH1A1HPGDS1PR1SMN1; SMN2MEN1 | |
| SCHEMBL7354913 | 0.73 | PDE4D (0.41) | PDE4APDE4BPDE4CPDE4DSMPD1 | |
| SCHEMBL11157473 | 0.73 | ALDH1A1 (0.49) | ALDH1A1HPGDS1PR1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4602026-A | 5-(3-ETHOXY-4-PENTYLOXYPHENYL)-2,4-THIAZOLIDINEDIONE | SENJU PHARMACEUTICAL CO., LTD. (JP) | 1986-07-22 | — | — | US | disclosed |
| US-4387101-A | ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1983-06-07 | — | — | US | disclosed |
| EP-0033617-A2 | Thiazolidine derivatives and their production and medicinal compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1981-08-12 | — | — | EP | disclosed |