Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.39 |
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6055497 | 0.80 | PDE4D (0.48) | PDE4DCALM1PDE4APDE4BPDE4C | |
| SCHEMBL16606362 | 0.79 | CYP3A4 (0.51) | PDE4DCALM1PPARGPPARA | |
| SCHEMBL30867116 | 0.77 | SMPD1 (0.41) | CALM1SMPD1PPARG | |
| SCHEMBL24866002 | 0.77 | SMPD1 (0.41) | CALM1SMPD1PPARG | |
| SCHEMBL6055250 | 0.75 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL9250450 | 0.75 | SMPD1 (0.43) | CALM1SMPD1 | |
| SCHEMBL10896158 | 0.73 | ALDH1A1 (0.44) | PDE4DSMPD1PDE4APDE4BPDE4C | |
| SCHEMBL2802608 | 0.73 | PDE4D (0.56) | PDE4DPPARGPPARAPDE4APDE4B | |
| SCHEMBL6055199 | 0.72 | PDE4D (0.62) | PDE4DPPARGPPARAPDE4APDE4B | |
| SCHEMBL7295579 | 0.72 | BIRC5 (0.57) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652247-A | VASOPRESSIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD (JP) | 1997-07-29 | — | — | US | disclosed |
| US-5436254-A | Vaopressin antagonists | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0602209-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |