Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | MMP8 | P22894 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | REN | P00797 | 14/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10522694 | 1.00 | MMP9 (0.44) | MMP9MMP8MMP2RENMMP14 | |
| SCHEMBL10899340 | 0.95 | MMP9 (0.42) | MMP9MMP8MMP2RENMMP14 | |
| SCHEMBL10522077 | 0.95 | MMP9 (0.42) | MMP9MMP8MMP2RENMMP14 | |
| SCHEMBL10521251 | 0.90 | MMP9 (0.44) | MMP9MMP8MMP2RENMMP14 | |
| SCHEMBL10897328 | 0.90 | MMP9 (0.44) | MMP9MMP8MMP2RENMMP14 | |
| SCHEMBL10901322 | 0.85 | MMP9 (0.42) | MMP9MMP8MMP2RENMMP14 | |
| SCHEMBL10520125 | 0.85 | MMP9 (0.42) | MMP9MMP8MMP2RENMMP14 | |
| Bromide SCHEMBL10635874 | 0.84 | MMP9 (0.45) | MMP9MMP8MMP2RENMMP14 | |
| Bromide SCHEMBL10976755 | 0.84 | MMP9 (0.45) | MMP9MMP8MMP2RENMMP14 | |
| SCHEMBL10519920 | 0.84 | MMP2 (0.50) | MMP9MMP8MMP2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |