Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL958662 | 0.82 | LMNA (0.51) | CNR2GAALMNAPTGS1 | |
| SCHEMBL3395153 | 0.80 | ALDH1A1 (0.42) | ALDH1A1TSHRCA2POLBMAPT | |
| SCHEMBL4936719 | 0.76 | ERCC5 (0.46) | TSHRPOLBELANENPC1RAB9A | |
| SCHEMBL7986988 | 0.75 | TDP1 (0.39) | ALDH1A1TDP1TSHRCA2ELANE | |
| SCHEMBL1148444 | 0.74 | ALDH1A1 (0.50) | ALDH1A1TDP1TSHRCA2POLB | |
| SCHEMBL895013 | 0.73 | KDM4E (0.52) | ALDH1A1TDP1TSHRCA2MAPT | |
| SCHEMBL11412880 | 0.73 | GABRA1 (0.44) | ALDH1A1TSHRGABRA1GABRB2 | |
| SCHEMBL360806 | 0.72 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRCA2POLB | |
| SCHEMBL7537141 | 0.72 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRCA2POLB | |
| SCHEMBL31028133 | 0.72 | ALDH1A1 (0.56) | ALDH1A1TDP1TSHRCA2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4563460-A | Quinoline and quinazoline derivatives for treating gastrointestinal motility dysfunctions | WILLIAM H. RORER, INC. (US) | 1986-01-07 | — | — | US | disclosed |