Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3431048 | 0.81 | NR3C2 (0.46) | MAPTKDM4EALDH1A1CYP3A4CYP2E1 | |
| SCHEMBL15218939 | 0.78 | NR4A1 (0.54) | MAPTKDM4EALDH1A1CYP3A4HTT | |
| SCHEMBL1926995 | 0.77 | ALDH1A1 (0.49) | MAPTKDM4EALDH1A1POLBCYP3A4 | |
| SCHEMBL12342913 | 0.76 | CYP3A4 (0.47) | KDM4EALDH1A1CYP3A4CYP2E1CYP2A6 | |
| SCHEMBL11624615 | 0.75 | ADH5 (0.46) | KDM4EALDH1A1CYP3A4CYP2E1CYP2A6 | |
| SCHEMBL27556239 | 0.74 | CYP3A4 (0.39) | ALDH1A1CYP3A4SMN1; SMN2CYP2E1CYP2A6 | |
| SCHEMBL3509305 | 0.72 | ICMT (0.55) | CYP3A4CYP2E1CYP2A6BDKRB2GRM5 | |
| SCHEMBL31253290 | 0.72 | AHR (0.34) | KDM4EALDH1A1CYP3A4CYP2E1CYP2A6 | |
| SCHEMBL265184 | 0.72 | ALDH1A1 (0.61) | MAPTALDH1A1CYP3A4GAACYP2E1 | |
| SCHEMBL19814656 | 0.71 | MAPT (0.44) | MAPTKDM4ERAD52ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4533669-A | NONTOXIC | EISAI CO., LTD. (JP) | 1985-08-06 | — | — | US | claimed |
| US-4602031-A | Anti-depressant imidazoles, compositions and use | EISAI CO., LTD. (JP) | 1986-07-22 | — | — | US | disclosed |
| US-4533669-A | NONTOXIC | EISAI CO., LTD. (JP) | 1985-08-06 | — | — | US | disclosed |
| US-4402966-A | Acylaminophenyl imidazoles and anti-depressing agent containing the same | EISAI CO., LTD. (JP) | 1983-09-06 | — | — | US | disclosed |
| US-4301169-A | Novel imidazole compound and anti-depressing agent containing the same | EISAI CO., LTD. (JP) | 1981-11-17 | — | — | US | disclosed |