Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.73 |
| ▸ | AR | P10275 | 4/20 | 0.73 |
| ▸ | F2 | P00734 | 1/20 | 0.73 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10903833 | 1.00 | PGR (0.73) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10900439 | 0.95 | PGR (0.66) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10900446 | 0.95 | PGR (0.66) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10939853 | 0.93 | PGR (0.70) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10939858 | 0.93 | PGR (0.70) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10906137 | 0.93 | NR3C1 (0.63) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10906135 | 0.93 | NR3C1 (0.63) | PGRCYP3A4ARF2NR3C1 | |
| Methylprednisolone Aceponate SCHEMBL8961317 | 0.93 | PGR (0.74) | PGRCYP3A4ARF2NR3C1 | |
| Methylprednisolone Aceponate SCHEMBL8612416 | 0.93 | PGR (0.74) | PGRCYP3A4ARF2NR3C1 | |
| Methylprednisolone Aceponate SCHEMBL3466 | 0.93 | PGR (0.74) | PGRCYP3A4ARF2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435390-A | Hydrocortisone derivatives, the preparation and use thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-03-06 | — | — | US | claimed |
| US-4567172-A | ANTINFLAMMATORY AGENTS, ANTIALLERGENS | OHTA SEIYAKU KABUSHIKI KAISHA (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4435390-A | Hydrocortisone derivatives, the preparation and use thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-03-06 | — | — | US | disclosed |
| EP-0095894-A2 | 6 Alpha-methylprednisolone derivatives | OHTA SEIYAKU KABUSHIKI KAISHA. (JP) | 1983-12-07 | — | — | EP | disclosed |