Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ACE | P12821 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.44 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10905028 | 0.82 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL12304830 | 0.77 | ACE (0.60) | SMN1; SMN2ACELMNAMEN1KMT2A | |
| SCHEMBL14374305 | 0.77 | ACE (0.60) | SMN1; SMN2ACELMNAMEN1KMT2A | |
| SCHEMBL11008763 | 0.76 | MME (0.68) | SMN1; SMN2ACELMNAMEN1KMT2A | |
| SCHEMBL4671532 | 0.76 | ACE (0.61) | SMN1; SMN2ACELMNAMEN1KMT2A | |
| SCHEMBL4671537 | 0.76 | ACE (0.61) | SMN1; SMN2ACELMNAMEN1KMT2A | |
| SCHEMBL8257832 | 0.76 | REN (0.56) | SMN1; SMN2ACELMNAMEN1KMT2A | |
| SCHEMBL8435225 | 0.76 | REN (0.56) | SMN1; SMN2ACELMNAMEN1KMT2A | |
| SCHEMBL5705166 | 0.75 | LMNA (0.42) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL497515 | 0.75 | ACE (0.60) | SMN1; SMN2ACELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4575503-A | ANGIOTENSIN CONVERTING ENZYME INHIBITOR, HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1986-03-11 | — | — | US | disclosed |
| US-4473575-A | ANGIOTENSIN INHIBITORS, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1984-09-25 | — | — | US | disclosed |
| US-4410520-A | ANGIOTENSION CONVERTING ENZYME INGIBITOR, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-10-18 | — | — | US | disclosed |