Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.83 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.83 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.83 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.83 |
| ▸ | HTR1A | P08908 | 1/20 | 0.83 |
| ▸ | PKM | P14618 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.80 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.80 |
| ▸ | TSHR | P16473 | 1/20 | 0.80 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.80 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.74 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.71 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.71 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.66 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13802251 | 0.92 | PTGS2 (0.84) | PTGS2HIF1APTGS1GLO1HTR1A | |
| SCHEMBL10519250 | 0.91 | PTGS2 (0.82) | PTGS2HIF1APTGS1GLO1HTR1A | |
| Acemetacin SCHEMBL23843 | 0.91 | PTGS2 (1.00) | PTGS2HIF1APTGS1GLO1HTR1A | |
| Acemetacin SCHEMBL29402955 | 0.91 | PTGS2 (1.00) | PTGS2HIF1APTGS1GLO1HTR1A | |
| SCHEMBL10515741 | 0.90 | PTGS2 (0.72) | PTGS2HIF1APTGS1GLO1HTR1A | |
| Acemetacin SCHEMBL10910170 | 0.90 | PTGS2 (0.98) | PTGS2HIF1APTGS1GLO1HTR1A | |
| Acemetacin SCHEMBL5400266 | 0.90 | PTGS2 (0.98) | PTGS2HIF1APTGS1GLO1HTR1A | |
| Acemetacin SCHEMBL5306430 | 0.89 | PTGS2 (0.96) | PTGS2HIF1APTGS1GLO1HTR1A | |
| SCHEMBL1082631 | 0.89 | HIF1A (1.00) | PTGS2HIF1APTGS1GLO1HTR1A | |
| SCHEMBL10516272 | 0.88 | AKR1C3 (0.82) | PTGS2HIF1APTGS1GLO1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4332727-A | BY CYCLIZING THE CORRESPONDING HYDRAZONE | TROPONWERKE GMBH & CO. KG (DE) | 1982-06-01 | — | — | US | claimed |
| US-4585880-A | Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxyacetic acid | TROPONWERKE GMBH & CO. KG (DE) | 1986-04-29 | — | — | US | disclosed |
| US-4477677-A | Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxyacetic acid | TROPONWERKE GMBH & CO. KG (DE) | 1984-10-16 | — | — | US | disclosed |
| US-4459415-A | Process for the preparation of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxyacetic acid | TROPONWERKE GMBH & CO. KG (DE) | 1984-07-10 | — | — | US | disclosed |
| US-4332727-A | BY CYCLIZING THE CORRESPONDING HYDRAZONE | TROPONWERKE GMBH & CO. KG (DE) | 1982-06-01 | — | — | US | disclosed |
| US-4332727-A | BY CYCLIZING THE CORRESPONDING HYDRAZONE | TROPONWERKE GMBH & CO. KG (DE) | 1982-06-01 | — | — | US | disclosed |