Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 12/20 | 0.46 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19719013 | 0.82 | ELANE (0.47) | ELANEPRTN3 | |
| SCHEMBL4887181 | 0.80 | ELANE (0.53) | ELANESMN1; SMN2MAPK1 | |
| SCHEMBL7106629 | 0.78 | ALDH1A1 (0.48) | ALDH1A1HSD17B10CFTRBRD4MMP2 | |
| SCHEMBL7391282 | 0.77 | ALDH1A1 (0.42) | ELANEALDH1A1HSD17B10CFTRBRD4 | |
| SCHEMBL14329352 | 0.76 | ALDH1A1 (0.43) | ALDH1A1HSD17B10CFTRBRD4MMP2 | |
| SCHEMBL10896090 | 0.76 | ALDH1A1 (0.46) | ELANEPRTN3ALDH1A1GLASMN1; SMN2 | |
| SCHEMBL9079554 | 0.75 | ALDH1A1 (0.41) | ALDH1A1HSD17B10CFTRBRD4MMP2 | |
| SCHEMBL7163203 | 0.71 | HSD17B10 (0.67) | ALDH1A1HSD17B10CFTRMMP2KDM4E | |
| SCHEMBL27615323 | 0.70 | ADRB1 (0.42) | ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL28030915 | 0.70 | ELANE (0.42) | ELANEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10176887-B1 | Ex vivo methods for drug discovery, development and testing | ORGAN RECOVERY SYSTEMS, INC. (US) | 2019-01-08 | — | — | US | claimed |
| US-10176887-B1 | Ex vivo methods for drug discovery, development and testing | ORGAN RECOVERY SYSTEMS, INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-4621053-A | Process for the production of human peptide hormones | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 1986-11-04 | — | — | US | disclosed |
| US-4618624-A | 3-amino-4-hydroxy(or alkoxy)phenethanolamine derivatives and pharmacologically-acceptable acid addition salts thereof for increasing the growth rate and/or improving the lean meat to fat ratio of warm-blooded animals | AMERICAN CYANAMID COMPANY (US) | 1986-10-21 | — | — | US | disclosed |
| EP-0080595-B1 | ALKANESULFONANILIDE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF | AMERICAN CYANAMID COMPANY (US) | 1985-05-29 | — | — | EP | disclosed |
| US-4477680-A | 3-Amino-4-hydroxy(or alkoxy)phenethanolamine derivatives and _pharmacologically acceptable acid addition salts thereof for _increasing the growth rate and/or improving the lean meat to fat _ratio of warm-blooded animals | AMERICAN CYANAMID COMPANY (US) | 1984-10-16 | — | — | US | disclosed |