Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10912433 | 0.69 | HPGD (0.47) | SMN1; SMN2KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL10912632 | 0.65 | POLB (0.33) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL207698 | 0.65 | NPC1 (0.44) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL3561735 | 0.65 | DAO (0.43) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL10801776 | 0.64 | TSHR (0.52) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL207697 | 0.63 | MEN1 (0.40) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL9850025 | 0.63 | ALOX5 (0.46) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL5353440 | 0.63 | NPC1 (0.43) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL11152903 | 0.62 | ALDH1A1 (0.41) | KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL10911166 | 0.62 | MAOA (0.42) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0074820-B1 | SUBSTITUTED PYRIMID-2-ONES, THE SALTS THEREOF, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NYEGAARD & CO. A/S (NO) | 1986-08-27 | — | — | EP | disclosed |
| US-4478839-A | CELL ANTIGROWTH AGENTS | NYEGAARD & CO. A/S (NO) | 1984-10-23 | — | — | US | disclosed |
| EP-0074820-A1 | Substituted pyrimid-2-ones, the salts thereof, processes for their preparation and pharmaceutical compositions containing them | NYEGAARD & CO. A/S (NO) | 1983-03-23 | — | — | EP | disclosed |