Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10911123 | 0.75 | KMT2A (0.45) | HPGDHTTALDH1A1KDM4EPKM | |
| SCHEMBL10915138 | 0.72 | KMT2A (0.40) | HPGDHTTALDH1A1KDM4EPKM | |
| SCHEMBL11152903 | 0.72 | ALDH1A1 (0.41) | HPGDHTTPOLBALDH1A1KDM4E | |
| SCHEMBL10911166 | 0.70 | MAOA (0.42) | ALDH1A1KDM4ETSHRSMN1; SMN2TDP1 | |
| SCHEMBL10912632 | 0.70 | POLB (0.33) | HTTPOLBALDH1A1KDM4ETSHR | |
| SCHEMBL10912430 | 0.69 | SMN1; SMN2 (0.37) | ALDH1A1LMNASMN1; SMN2KMT2AMAPT | |
| SCHEMBL11243480 | 0.68 | LMNA (0.52) | HPGDPOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL18415485 | 0.67 | POLB (0.72) | HPGDHTTPOLBALDH1A1KDM4E | |
| SCHEMBL14142610 | 0.67 | LMNA (0.80) | HPGDHTTPOLBALDH1A1KDM4E | |
| SCHEMBL10801776 | 0.66 | TSHR (0.52) | HPGDHTTPOLBALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0074820-B1 | SUBSTITUTED PYRIMID-2-ONES, THE SALTS THEREOF, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NYEGAARD & CO. A/S (NO) | 1986-08-27 | — | — | EP | disclosed |
| US-4478839-A | CELL ANTIGROWTH AGENTS | NYEGAARD & CO. A/S (NO) | 1984-10-23 | — | — | US | disclosed |
| EP-0074820-A1 | Substituted pyrimid-2-ones, the salts thereof, processes for their preparation and pharmaceutical compositions containing them | NYEGAARD & CO. A/S (NO) | 1983-03-23 | — | — | EP | disclosed |