Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | HEXA | P06865 | 1/20 | 0.39 |
| ▸ | HEXB | P07686 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL10909850 | 0.94 | RAB9A (0.40) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| Dimethylamine SCHEMBL10912082 | 0.94 | RAB9A (0.45) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| Diethylamine SCHEMBL10913070 | 0.93 | RAB9A (0.39) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| Dimethylamine SCHEMBL10913743 | 0.87 | RAB9A (0.41) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| Diethylamine SCHEMBL10911941 | 0.86 | PDE10A (0.40) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| Dimethylamine SCHEMBL10914075 | 0.86 | RAB9A (0.43) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| Diethylamine SCHEMBL10912187 | 0.85 | HTR1A (0.40) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL10914068 | 0.83 | PABPC1 (0.45) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL10912465 | 0.82 | MAOB (0.43) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL10912075 | 0.82 | ALDH1A1 (0.47) | RAB9ANPC1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0171977-A1 | Phthalimide derivatives, compositions containing them and a process for preparing them | SANKYO COMPANY LIMITED (JP) | 1986-02-19 | — | — | EP | disclosed |