Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP51A1 | Q16850 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR1E | P28566 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10911463 | 0.76 | LMNA (0.40) | SLC6A4GPR84HTR2ANR4A2 | |
| SCHEMBL28417664 | 0.74 | GPR84 (0.42) | SLC6A4GPR84HTR2AHTR2CHTR2B | |
| SCHEMBL20458837 | 0.72 | GPR84 (0.44) | SLC6A4GPR84HTR2AHTR2CHTR2B | |
| SCHEMBL22095932 | 0.71 | GPR84 (0.44) | SLC6A4GPR84HTR2AHTR2CHTR2B | |
| SCHEMBL25248962 | 0.68 | CYP51A1 (0.36) | CYP51A1HTR1D | |
| SCHEMBL30565982 | 0.68 | CYP51A1 (0.36) | CYP51A1HTR1D | |
| SCHEMBL10911462 | 0.68 | MDM2 (0.38) | GPR84NR4A2 | |
| SCHEMBL24243710 | 0.66 | HTR2A (0.63) | HTR1ASLC6A4HTR1DGPR84HTR2A | |
| SCHEMBL8912272 | 0.65 | HTR2C (0.51) | HTR1AHTR1DGPR84HTR2AHTR2C | |
| SCHEMBL10262953 | 0.65 | GPR84 (0.58) | HTR1ASLC6A4GPR84HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0099766-B1 | 1-3-DIHYDRO 4-(1-HYDROXY-2-AMINO-ETHYL)-2H-INDOL-2-ONE DERIVATIVES, THEIR SALTS, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1986-04-09 | — | — | EP | disclosed |