Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10924690 | 0.77 | HTT (0.39) | LMNAGAAPOLBCA1CA2 | |
| SCHEMBL7487387 | 0.76 | ALDH1A1 (0.48) | SRD5A2GAAL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL6326821 | 0.76 | SRD5A2 (0.56) | SRD5A2LMNAGAAL3MBTL1CES1 | |
| SCHEMBL975118 | 0.75 | SRD5A2 (0.83) | SRD5A2LMNAGAAL3MBTL1CES1 | |
| SCHEMBL10723714 | 0.75 | SRD5A2 (0.83) | SRD5A2LMNAGAAL3MBTL1CES1 | |
| SCHEMBL29360098 | 0.71 | IGFBP3 (0.47) | GAAL3MBTL1POLBCA1CA2 | |
| SCHEMBL10920493 | 0.71 | PDE4A (0.60) | SRD5A2LMNAGAAL3MBTL1CES1 | |
| SCHEMBL29191028 | 0.71 | SRD5A2 (0.63) | SRD5A2LMNAGAAL3MBTL1CES1 | |
| SCHEMBL28914440 | 0.70 | MAPK1 (0.85) | SRD5A2LMNAGAAL3MBTL1CES1 | |
| SCHEMBL6231410 | 0.70 | LMNA (0.51) | SRD5A2LMNAGAAL3MBTL1CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3131545-B1 | USE OF ENOXIMONE IN THE TREATMENT OF ATOPIC IMMUNE-RELATED DISORDERS, IN PHARMACEUTICAL COMPOSITIONS AS WELL AS IN PHARMACEUTICAL PREPARATIONS | BREAKTHROUGH MEDICAL RES B V (NL) | 2024-05-29 | — | — | EP | disclosed |
| US-20230270724-A1 | PDE3 inhibitors for treating viral infections | BREAKTHROUGH MEDICAL RESEARCH B.V. (NL) | 2023-08-31 | — | — | US | disclosed |
| CN-116171151-A | PDE3 inhibitors for the treatment of viral infections | 突破医学研究公司 | 2023-05-26 | — | — | CN | disclosed |
| EP-4181887-A1 | PDE3 INHIBITORS FOR TREATING VIRAL INFECTIONS | Breakthrough Medical Research B.V. (NL) | 2023-05-24 | — | — | EP | disclosed |
| WO-2022018085-A1 | PDE3 INHIBITORS FOR TREATING VIRAL INFECTIONS | BREAKTHROUGH MEDICAL RESEARCH B.V. (NL) | 2022-01-27 | — | — | WO | disclosed |
| EP-3763365-A1 | AROYLIMIDAZOLONES FOR THE TREATMENT OF THAUMETOPOEA EXPOSURE | Breakthrough Medical Research B.V. (NL) | 2021-01-13 | — | — | EP | disclosed |
| US-10071077-B2 | Use of enoximone in the treatment of atopic immune-related disorders, in pharmaceutical composition as well as in pharmaceutical preparation | BREAKTHROUGH MEDICAL RESEARCH B.V. (NL) | 2018-09-11 | — | — | US | disclosed |
| EP-3131545-A2 | USE OF ENOXIMONE IN THE TREATMENT OF ATOPIC IMMUNE-RELATED DISORDERS, IN PHARMACEUTICAL COMPOSITION AS WELL AS IN PHARMACEUTICAL PREPARATION | Breakthrough Medical Research B.V. (NL) | 2017-02-22 | — | — | EP | disclosed |
| US-20170035735-A1 | Use Of Enoximone In The Treatment Of Atopic Immune-Related Disorders, In Pharmaceutical Composition As Well As In Pharmaceutical Preparation | BREAKTHROUGH MEDICAL RESEARCH B.V. (NL) | 2017-02-09 | — | — | US | disclosed |
| WO-2015160249-A2 | USE OF ENOXIMONE IN THE TREATMENT OF ATOPIC IMMUNE-RELATED DISORDERS, IN PHARMACEUTICAL COMPOSITION AS WELL AS IN PHARMACEUTICAL PREPARATION | BREAKTHROUGH MEDICAL RESEARCH B.V. (NL) | 2015-10-22 | — | — | WO | disclosed |
| EP-0058435-B1 | NOVEL 4-AROYLIMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-12-30 | — | — | EP | disclosed |
| EP-0059948-B1 | NOVEL AROYLIMIDAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-11-13 | — | — | EP | disclosed |
| US-4405635-A | HYPOTENSIVE, CARDIOTONIC, BRONCHODILATOR, ANTICOAGULANT, AND MUSCLE RELAXANT AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |
| EP-0058435-A2 | Novel 4-aroylimidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-08-25 | — | — | EP | disclosed |