SCHEMBL6984658

SCHEMBL6984658

Nc1nc(N)nc(-c2ccccc2N2CCCCC2)n1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 1/20 0.53
ALDH1A1 P00352 4/20 0.49
SMN1; SMN2 Q16637 1/20 0.47
NCF1 P14598 1/20 0.45
NR1I2 O75469 2/20 0.44
SMARCA2 P51531 2/20 0.44
SMARCA4 P51532 2/20 0.44
PBRM1 Q86U86 2/20 0.44
DHFR P00374 1/20 0.44
HSD17B10 Q99714 3/20 0.44
USP2 O75604 2/20 0.44
LMNA P02545 2/20 0.44
TSHR P16473 2/20 0.44
HTT P42858 1/20 0.44
HRH4 Q9H3N8 1/20 0.43
MAPK1 P28482 3/20 0.43
PTGS2 P35354 1/20 0.43
NPC1 O15118 1/20 0.42
EGFR P00533 1/20 0.41
RAF1 P04049 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10923366 0.75 HRH4 (0.75) ALDH1A1SMN1; SMN2HSD17B10HTTHRH4
SCHEMBL17046876 0.73 SMN1; SMN2 (0.71) ALDH1A1SMN1; SMN2TSHRHRH4NPC1
SCHEMBL30468191 0.73 SMN1; SMN2 (0.71) ALDH1A1SMN1; SMN2TSHRHRH4NPC1
SCHEMBL3803039 0.73 ADORA2A (0.55) KEAP1ALDH1A1SMN1; SMN2NCF1NR1I2
SCHEMBL7130590 0.72 PTGS2 (0.60) KEAP1ALDH1A1NR1I2SMARCA2SMARCA4
SCHEMBL3760226 0.71 KEAP1 (0.42) KEAP1ALDH1A1SMN1; SMN2NR1I2SMARCA2
SCHEMBL27934132 0.71 MAPK1 (0.74) KEAP1ALDH1A1NCF1HSD17B10TSHR
SCHEMBL27876080 0.71 HTR7 (0.67) KEAP1ALDH1A1DHFRTSHRMAPK1
SCHEMBL13039956 0.71 HTR7 (0.67) KEAP1ALDH1A1DHFRTSHRMAPK1
SCHEMBL1084304 0.70 CYP2D6 (0.59) ALDH1A1SMN1; SMN2NCF1HSD17B10USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1037886-B1 TRIAZINE ANGIOGENESIS INHIBITORS ABBOTT LAB (US) 2003-05-02 EP claimed
US-6288228-B1 DIAMINOTRIAZINE DERIVATIVES ABBOTT LABORATORIES 2001-09-11 US claimed
US-6150362-A ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES ABBVIE INC. 2000-11-21 US claimed
EP-1037886-A1 TRIAZINE ANGIOGENESIS INHIBITORS Abbott Laboratories (US) 2000-09-27 EP claimed
WO-1999031088-A1 TRIAZINE ANGIOGENESIS INHIBITORS ABBOTT LABORATORIES (US) 1999-06-24 WO claimed
EP-1037886-B1 TRIAZINE ANGIOGENESIS INHIBITORS ABBOTT LAB (US) 2003-05-02 EP disclosed
US-6288228-B1 DIAMINOTRIAZINE DERIVATIVES ABBOTT LABORATORIES 2001-09-11 US disclosed
US-6150362-A ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES ABBVIE INC. 2000-11-21 US disclosed