Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.71 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10921763 | 1.00 | AKR1B1 (0.71) | AKR1B1AKR1B10MAPTAKR1A1 | |
| Sorbinil SCHEMBL2108408 | 0.83 | AKR1B10 (1.00) | AKR1B1AKR1B10MAPTAKR1A1 | |
| Sorbinil SCHEMBL17223865 | 0.83 | AKR1B10 (1.00) | AKR1B1AKR1B10MAPTAKR1A1 | |
| Sorbinil SCHEMBL9790028 | 0.83 | AKR1B10 (1.00) | AKR1B1AKR1B10MAPTAKR1A1 | |
| SCHEMBL1982939 | 0.83 | AKR1B10 (0.71) | AKR1B1AKR1B10MAPTAKR1A1 | |
| Sorbinil SCHEMBL29599732 | 0.83 | AKR1B10 (1.00) | AKR1B1AKR1B10MAPTAKR1A1 | |
| SCHEMBL11342164 | 0.83 | AKR1B1 (0.71) | AKR1B1AKR1B10MAPTAKR1A1 | |
| Sorbinil SCHEMBL48877 | 0.83 | AKR1B10 (1.00) | AKR1B1AKR1B10MAPTAKR1A1 | |
| SCHEMBL11345193 | 0.82 | AKR1B1 (0.62) | AKR1B1AKR1B10MAPTAKR1A1 | |
| SCHEMBL10631494 | 0.80 | AKR1B1 (0.66) | AKR1B1AKR1B10MAPTAKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4147795-A | ENZYME INHIBITORS | PFIZER INC. (US) | 1979-04-03 | — | — | US | claimed |
| EP-0037672-B1 | PROCESS FOR THE PREPARATION OF CHIRAL HYDANTOINS, AND A NOVEL HYDANTOIN PRODUCED BY SAID PROCESS AND A PHARMACEUTICAL COMPOSITION CONTAINING IT | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |
| US-4419521-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1983-12-06 | — | — | US | disclosed |
| EP-0034063-B1 | HYDANTOIN AMINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 1983-06-22 | — | — | EP | disclosed |
| US-4348526-A | COMPLICATIONS OF DIABETES | PFIZER INC. (US) | 1982-09-07 | — | — | US | disclosed |
| EP-0037672-A2 | Process for the preparation of chiral hydantoins, and a novel hydantoin produced by said process and a pharmaceutical composition containing it | PFIZER INC. (US) | 1981-10-14 | — | — | EP | disclosed |
| US-4286098-A | HYPOGLYCEMIC AGENTS, TREATMENT OF DIABETES COMPLICATIONS | PFIZER INC. (US) | 1981-08-25 | — | — | US | disclosed |
| EP-0034063-A1 | Hydantoin amines and pharmaceutical compositions thereof | PFIZER INC. (US) | 1981-08-19 | — | — | EP | disclosed |
| US-4282229-A | FOR DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |
| US-4258054-A | ANTIDIABETIC | PFIZER INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4258054-A | ANTIDIABETIC | PFIZER INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4248882-A | ENZYME INHIBITOR FOR NEUROPATHY, RETINOPATHY, CATARACTS | PFIZER INC. (US) | 1981-02-03 | — | — | US | disclosed |
| US-4210756-A | Tetrahydroquinoline hydantoins for chronic diabetic complications | PFIZER INC. (US) | 1980-07-01 | — | — | US | disclosed |
| US-4209630-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1980-06-24 | — | — | US | disclosed |
| US-4209630-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1980-06-24 | — | — | US | disclosed |
| US-4147795-A | ENZYME INHIBITORS | PFIZER INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-4147795-A | ENZYME INHIBITORS | PFIZER INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-4117230-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1978-09-26 | — | — | US | disclosed |
| US-4117230-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1978-09-26 | — | — | US | disclosed |