Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.71 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24697564 | 0.89 | AKR1B1 (0.59) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL2108408 | 0.83 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL17223865 | 0.83 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL9790028 | 0.83 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL11342164 | 0.83 | AKR1B1 (0.71) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL10921763 | 0.83 | AKR1B1 (0.71) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL29599732 | 0.83 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL10923913 | 0.83 | AKR1B1 (0.71) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL48877 | 0.83 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL1978795 | 0.82 | AKR1B1 (0.70) | AKR1B10MAPTAKR1A1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |
| US-4282229-A | FOR DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |
| US-4258054-A | ANTIDIABETIC | PFIZER INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4210756-A | Tetrahydroquinoline hydantoins for chronic diabetic complications | PFIZER INC. (US) | 1980-07-01 | — | — | US | disclosed |
| US-4209630-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1980-06-24 | — | — | US | disclosed |
| US-4147795-A | ENZYME INHIBITORS | PFIZER INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-4117230-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1978-09-26 | — | — | US | disclosed |