SCHEMBL10926019

SCHEMBL10926019

O=C1CCSC(c2ccccc2F)c2cc(Cl)ccc2N1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.60
TP53 P04637 3/20 0.60
CYP1A2 P05177 2/20 0.60
CYP2C19 P33261 2/20 0.60
TSHR P16473 2/20 0.60
CYP2C9 P11712 1/20 0.60
ALOX15 P16050 1/20 0.60
CASP1 P29466 1/20 0.60
RECQL P46063 1/20 0.60
SLC8B1 Q6J4K2 1/20 0.60
LMNA P02545 2/20 0.42
ATM Q13315 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
AHR P35869 1/20 0.37
CACNB4 O00305 1/20 0.36
CACNA1A O00555 1/20 0.36
CACNA1G O43497 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10929981 0.88 MAPT (0.77) MAPTTP53CYP1A2CYP2C19TSHR
SCHEMBL10930085 0.79 LMNA (0.51) MAPTTP53CYP1A2CYP2C19TSHR
SCHEMBL11090465 0.75 MAPT (0.45) MAPTTP53CYP1A2CYP2C19TSHR
SCHEMBL869274 0.75 TP53 (1.00) MAPTTP53CYP1A2CYP2C19TSHR
SCHEMBL31071906 0.75 TP53 (1.00) MAPTTP53CYP1A2CYP2C19TSHR
SCHEMBL10044117 0.74 TP53 (0.79) MAPTTP53CYP1A2CYP2C19TSHR
SCHEMBL10929004 0.73 MAPT (0.56) MAPTTP53CYP1A2CYP2C19TSHR
SCHEMBL4590461 0.71 CACNB4 (0.47) MAPTTP53CYP1A2CYP2C19TSHR
SCHEMBL27729051 0.70 KDM1A (0.39) CYP1A2CYP2C19LMNACYP3A4CYP2D6
SCHEMBL8117192 0.69 MAPT (0.60) MAPTTP53CYP1A2CYP2C19TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0072029-B1 TRIAZOLOBENZAZEPINES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1986-10-22 EP disclosed
US-4464300-A PSYCHOTROPIC, ANXIOLYTIC AGENTS HOFFMANN-LA ROCHE INC. (US) 1984-08-07 US disclosed
EP-0072029-A2 Triazolobenzazepines, process and intermediates for their preparation and medicines containing them F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1983-02-16 EP disclosed