Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 2/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8117192 | 0.87 | MAPT (0.60) | LMNAMAPTTSHRTP53CYP1A2 | |
| SCHEMBL8921094 | 0.85 | LMNA (0.52) | LMNAMAPTDDB1CRBNALDH1A1 | |
| SCHEMBL10925308 | 0.85 | CHRM1 (0.45) | LMNAMAPTTSHRTP53CYP1A2 | |
| SCHEMBL8922488 | 0.83 | DDB1 (0.55) | LMNAMAPTTSHRTP53CYP1A2 | |
| SCHEMBL10926019 | 0.79 | MAPT (0.60) | LMNAMAPTTSHRTP53CYP1A2 | |
| SCHEMBL11090465 | 0.78 | MAPT (0.45) | LMNAMAPTTSHRTP53CYP1A2 | |
| SCHEMBL25575904 | 0.76 | DDB1 (0.67) | LMNADDB1CRBNALDH1A1 | |
| SCHEMBL4590461 | 0.74 | CACNB4 (0.47) | LMNAMAPTTSHRTP53CYP1A2 | |
| SCHEMBL8922504 | 0.74 | DDB1 (0.50) | MAPTTSHRTP53CYP1A2CYP2C9 | |
| SCHEMBL8920256 | 0.74 | LMNA (0.54) | LMNAMAPTTSHRTP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0072029-B1 | TRIAZOLOBENZAZEPINES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-10-22 | — | — | EP | disclosed |
| US-4464300-A | PSYCHOTROPIC, ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1984-08-07 | — | — | US | disclosed |
| EP-0072029-A2 | Triazolobenzazepines, process and intermediates for their preparation and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-02-16 | — | — | EP | disclosed |