Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | CASP1 | P29466 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.42 |
| ▸ | GABRD | O14764 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8102823 | 0.87 | DDB1 (0.48) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL10930085 | 0.87 | LMNA (0.51) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL8922488 | 0.85 | DDB1 (0.55) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL25575865 | 0.78 | DDB1 (0.67) | DDB1CRBNGAAALDH1A1 | |
| SCHEMBL10929981 | 0.78 | MAPT (0.77) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL11085842 | 0.77 | MAPT (0.55) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL8922504 | 0.76 | DDB1 (0.50) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL8920256 | 0.76 | LMNA (0.54) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL1347279 | 0.76 | AHR (0.46) | MAPTTP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL31071906 | 0.75 | TP53 (1.00) | MAPTTP53CYP1A2CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0645378-B1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-5698691-A | ANTICHOLESTEROL AGENT; SYNTHETASE INHIBITOR; FUNGICIDE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0645378-A1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | Takeda Chemical Industries, Ltd. (JP) | 1995-03-29 | — | — | EP | disclosed |